Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …

Chronic disruption of rhythms (CDR) impacts sleep and can result in circadian misalignment
of physiological systems which, in turn, is associated with increased disease risk. Exposure …

Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver malignancy. The
interplay between bile acids (BAs) and the gut microbiota has emerged as a critical factor in …

Background: Liver injury commonly occurs in patients with COVID-19. There is limited data
describing the course of liver injury occurrence in patients with different disease severity …

Aim. Chlorogenic acid (CGA) is a natural polyphenolic compound found in human dietary
products. Previous studies have confirmed that CGA has many biological activities, such as …

Abstract Fibroblast growth factor 21 (FGF21) was originally identified as an important
metabolic regulator which plays a crucial physiological role in regulating a variety of …

The role of Tibet kefir milk (TKM) feeding on fat deposition was investigated in high-fat diet
(HFD)-fed human flora-associated (HFA) rats. TKM feeding reduced abdominal fat mass …

Cholestasis is a kind of stressful syndrome along with liver toxicity, which has been
demonstrated to be related to fibrosis, cirrhosis, even cholangiocellular or hepatocellular …

Cholestasis is characterized by hepatic accumulation of cytotoxic bile acids (BAs), which
often subsequently leads to liver injury, inflammation, fibrosis, and liver cirrhosis. Fibroblast …