Autophagy is a cytoplasmic degradation system, which is important for starvation adaptation
and cellular quality control. Recent advances in understanding autophagy highlight its …

Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …

Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to
treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Parkinson's disease (PD) is associated with the degeneration of ventral midbrain
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …

Parkinson's disease-causing mutations in the leucine-rich repeat kinase 2 (LRRK2) gene
hyperactivate LRRK2 kinase activity and cause increased phosphorylation of Rab GTPases …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the
preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction …

In Parkinsons disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra
pars compacta is associated with Lewy bodies arising from the accumulation of alpha …

Microglia are the most abundant immune cells in the central nervous system (CNS), where
they interact with neurons and exhibit a wide array of functions in physiological and …