In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-
order structures that contribute to their stability and to their participation in inter-and …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
COVID-19, the disease at the center of the current global pandemic. While knowledge of …

RNA is a versatile macromolecule that accommodates functional information in primary
sequence and secondary and tertiary structure. We use a combination of chemical probing …

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of
liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA …

Triggering and propagating an intracellular innate immune response is essential for control
of viral infections. RNase L is a host endoribonuclease and a pivotal component of innate …

HCV (hepatitis C virus) infects nearly 3% of the population worldwide and has emerged as a
major causative agent of liver disease, resulting in acute and chronic infections that can lead …

The ultimate outcome of the coronavirus disease 2019 (COVID-19) pandemic is unknown
and is dependent on a complex interplay of its pathogenicity, transmissibility, and population …

An estimated 3% of the world population is infected with hepatitis C virus (HCV)(5, 232). In
most infected individuals, this remarkable RNA virus evades the immune system and …

The mechanism and role of RNA structure elements in the replication and translation of
Caliciviridae remains poorly understood. Several algorithmically independent methods were …