An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Identified 50 years ago, mesenchymal stromal/stem cells (MSCs) immediately generated a
substantial interest among the scientific community because of their differentiation plasticity …

Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a
perspective for therapeutic use in immune and inflammatory diseases. Indeed …

Gut mucosal barriers, including chemical and physical barriers, spatially separate the gut
microbiota from the host immune system to prevent unwanted immune responses that could …

Thirty years after initial publications of the concept of a chimeric antigen receptor (CAR), the
US Food and Drug Administration (FDA) approved the first anti-CD19 CAR T-cell therapy …

Inflammation plays a central role in wound healing following injury or disease and is
mediated by a precise cascade of cellular and molecular events. Unresolved inflammatory …

Radiation therapy is one of the most important treatment modalities for thoracic tumors.
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …

The introduction of advanced therapy medicinal products (ATMPs) to the global pharma
market has been revolutionizing the pharmaceutical industry and has opened new routes for …

Background: Cell and gene therapy products belong to a diverse class of
biopharmaceuticals known as advanced therapy medicinal products. Cell and gene therapy …

The clinical application of ex vivo gene edited cell therapies first began a decade ago with
zinc finger nuclease editing of autologous CD4+ T-cells. Editing aimed to disrupt expression …