Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Presynaptic kainate (KA) receptors (KARs) modulate GABA and glutamate release in the
central nervous system of mammals. While some of the actions of KARs are ionotropic …

Ionotropic glutamate receptors (iGluRs) play key roles for signaling in the central nervous
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …

The main strategy for the treatment of epilepsy is the use of pharmacological agents known
as antiseizure medication (ASM). These drugs control the seizure onset and improves the …

The CRMP2 and CRMP4 proteins are strongly expressed in the developing nervous system,
mediating neurite outgrowth, neuronal polarity, and axon guidance. In the present study, we …

Kainate receptors (KARs) are highly expressed in the immature brain and have unique
developmentally regulated functions that may be important in linking neuronal activity to …

Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors
on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic …

Perturbed information processing in the amygdala has been implicated in developmentally
originating neuropsychiatric disorders. However, little is known on the mechanisms that …

During neuronal development, AMPA receptors (AMPARs) and NMDA receptors (NMDARs)
are important for neuronal differentiation. Kainate receptors (KARs) are closely related to …

In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and
oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress …