Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …

Interoception, the ability to timely and precisely sense changes inside the body, is critical for
survival,,–. Vagal sensory neurons (VSNs) form an important body-to-brain connection …

Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …

Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …

Almost all biomedical research to date has relied upon mean measurements from cell
populations, however it is well established that what it is observed at this macroscopic level …

Evidence suggests an association between severe acute respiratory syndrome–cornavirus-
2 (SARS-CoV-2) infection and the occurrence of new-onset diabetes. We examined …