Contemporary techniques and potential transungual drug delivery nanosystems for the treatment of onychomycosis

WH Abd-Elsalam, SM Abouelatta - AAPS PharmSciTech, 2023 - Springer
The humanoid nail is considered an exceptional protective barrier that is formed mainly from
keratin. Onychomycosis is the cause of 50% of nail infections that is generally caused by …

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

F Raza, H Zafar, L Jiang, J Su, W Yuan, M Qiu… - Biomaterials …, 2024 - pubs.rsc.org
In recent years, considerable attention has been given to phototherapy, including
photothermal and photodynamic therapy to kill tumor cells by producing heat or reactive …

Preparation and characteristics of a thermosensitive in situ gel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol

C Huang, L Peng, X Xu, Y Lu, X Wang, Z Lan… - Journal of Drug Delivery …, 2023 - Elsevier
To enhance the antimicrobial activity of chloramphenicol (CAP) and extend ocular retention,
chitosan nanoparticles carrying chloramphenicol (CAP-CNPs) were prepared by ionotropic …

Thermosensitive gels of pullulan and poloxamer 407 as potential injectable biomaterials

M Bercea, M Constantin, IA Plugariu… - Journal of Molecular …, 2022 - Elsevier
The paper presents the preparation and rheological response of thermosensitive gels of
poloxamer 407 (P407) in the presence of a versatile polysaccharide, pullulan (PULL). Prior …

Chitosan nanoparticles loaded poloxamer 407 Gel for transungual delivery of terbinafine HCl

KH Ullah, F Rasheed, I Naz, N Ul Haq, H Fatima… - Pharmaceutics, 2022 - mdpi.com
The current study aimed to develop chitosan nanoparticles (CSNP) loaded poloxamer 407
(P407) gel formulation for transungual delivery of terbinafine HCl (TBN). TBN-CSNP were …

Strategies for the enhancement of nail plate permeation of drugs to treat onychomycosis

AK Gupta, S Polla Ravi, SY Choi… - Journal of the …, 2023 - Wiley Online Library
Onychomycosis is caused by dermatophytes, non‐dermatophytes and yeasts. It has a global
prevalence of 5.5%, requires long treatment periods, and has high relapse rates following …

Enhanced oral bioavailability of mt-102, a new anti-inflammatory agent, via a ternary solid dispersion formulation

R Bajracharya, JG Song, SH Lee, SH Jeong, HK Han - Pharmaceutics, 2022 - mdpi.com
This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory
agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly …

New Biopharmaceutical Characteristics of In Situ Systems Based on Poloxamer 407

EO Bakhrushina, EV Novozhilova, MM Shumkova… - Gels, 2023 - mdpi.com
Thermosensitive systems based on poloxamer 407 are widely used in targeted drug
delivery; however, the stability of the phase transition temperature remains insufficiently …

[HTML][HTML] Functionalized surface of PLGA nanoparticles in thermosensitive gel to enhance the efficacy of antibiotics against antibiotic resistant infections in endodontics …

MG Arafa, HA Mousa, MM Kataia… - International Journal of …, 2023 - Elsevier
Enterococcus faecalis plays the key role in endodontic infections and is responsible for the
formation of biofilm on dentin, which causes a resistance against periradicular lesions …

Preparation and Antibacterial Activity Evaluation of Daphnetin-Loaded Poloxamers/Polyvinylpyrrolidone Thermosensitive Hydrogels

J Fan, F An, S Li, Y Guo, H Zhang, Y Zhang… - ACS Applied Bio …, 2024 - ACS Publications
Antibiotic misuse and bacterial resistance are pressing issues threatening public health.
Natural plant extracts with bactericidal properties offer potential alternatives to reduce or …