Biology of gastrointestinal stromal tumors

CL Corless, JA Fletcher, MC Heinrich - Journal of Clinical Oncology, 2004 - ascopubs.org
Once a poorly defined pathologic oddity, in recent years, gastrointestinal stromal tumor
(GIST) has emerged as a distinct oncogenetic entity that is now center stage in clinical trials …

NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)—update of the NCCN clinical practice guidelines

GD Demetri, RS Benjamin, CD Blanke, JY Blay… - Journal of the National …, 2007 - jnccn.org
The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment
recommendations for gastrointestinal stromal tumors (GISTs). The standard of practice …

NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors

GD Demetri, M Von Mehren, CR Antonescu… - Journal of the National …, 2010 - jnccn.org
Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal
tumors of the gastrointestinal tract. Neoplastic GIST cells seem to arise from a common …

Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival

RP DeMatteo, JJ Lewis, D Leung, SS Mudan… - Annals of …, 2000 - journals.lww.com
Objective To analyze the outcome of 200 patients with gastrointestinal stromal tumor (GIST)
who were treated at a single institution and followed up prospectively. Summary Background …

Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial

RP DeMatteo, KV Ballman, CR Antonescu, RG Maki… - The lancet, 2009 - thelancet.com
Background Gastrointestinal stromal tumour is the most common sarcoma of the intestinal
tract. Imatinib mesylate is a small molecule that inhibits activation of the KIT and platelet …

Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up

M Miettinen, LH Sobin, J Lasota - The American journal of …, 2005 - journals.lww.com
Gastrointestinal (GI) stromal tumors (GISTs), the specific KIT-or PDFGRA-signaling driven
mesenchymal tumors, are the most common mesenchymal tumors of the GI tract. In this …

Soft tissue sarcomas

JN Cormier, RE Pollock - CA: a cancer journal for clinicians, 2004 - Wiley Online Library
Sarcomas are a heterogeneous group of rare tumors that arise predominantly from the
embryonic mesoderm. They present most commonly as an asymptomatic mass originating in …

Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal …

JS Gold, M Gönen, A Gutiérrez, JM Broto… - The lancet …, 2009 - thelancet.com
Background Adjuvant imatinib mesylate prolongs recurrence-free survival (RFS) after
resection of localised primary gastrointestinal stromal tumours (GIST). We aimed to develop …

The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000

T Tran, JA Davila, HB El-Serag - Official journal of the American …, 2005 - journals.lww.com
OJECTIVES The epidemiology of gastrointestinal stromal tumor has not been well
examined, and prior studies often provide conflicting results. We conducted the first …

Gastrointestinal stromal tumour

BP Rubin, MC Heinrich, CL Corless - The Lancet, 2007 - thelancet.com
Gastrointestinal stromal tumours are the most common mesenchymal neoplasm of the
gastrointestinal tract and are highly resistant to conventional chemotherapy and …