Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

LP Jordheim, D Durantel, F Zoulim… - Nature reviews Drug …, 2013 - nature.com
Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …

Non-lamellar lyotropic liquid crystalline lipid nanoparticles for the next generation of nanomedicine

J Zhai, C Fong, N Tran, CJ Drummond - ACS nano, 2019 - ACS Publications
Nonlamellar lyotropic liquid crystalline (LLC) lipid nanomaterials have emerged as a
promising class of advanced materials for the next generation of nanomedicine, comprising …

Lipid–drug conjugate for enhancing drug delivery

D Irby, C Du, F Li - Molecular pharmaceutics, 2017 - ACS Publications
Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices

E Lepeltier, C Bourgaux, P Couvreur - Advanced drug delivery reviews, 2014 - Elsevier
Biodegradable nanocarriers such as lipid-or polymer-based nanoparticles can be designed
to improve the efficacy and reduce the toxic side effects of drugs. Under appropriate …

Squalene: A natural triterpene for use in disease management and therapy

LH Reddy, P Couvreur - Advanced drug delivery reviews, 2009 - Elsevier
Squalene is a natural lipid belonging to the terpenoid family and a precursor of cholesterol
biosynthesis. It is synthesized in humans and also in a wide array of organisms and …

Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems

J Kuntsche, JC Horst, H Bunjes - International journal of pharmaceutics, 2011 - Elsevier
Cryogenic transmission electron microscopy (cryo-TEM) has evolved into an indispensable
tool for the characterization of colloidal drug delivery systems. It can be applied to study the …

Nanomedicine and drug delivery systems in cancer and regenerative medicine

E Garbayo, S Pascual‐Gil… - Wiley …, 2020 - Wiley Online Library
Nanomedicine and drug delivery technologies play a prominent role in modern medicine,
facilitating better treatments than conventional drugs. Nanomedicine is being increasingly …

Prodrug-based intracellular delivery of anticancer agents

L Bildstein, C Dubernet, P Couvreur - Advanced drug delivery reviews, 2011 - Elsevier
There are numerous anticancer agents based on a prodrug approach. However, no attempt
has been made to review the ample available literature with a specific focus on the altered …

Squalene–biochemistry, molecular biology, process biotechnology, and applications

M Spanova, G Daum - European journal of lipid science and …, 2011 - Wiley Online Library
Squalene is a natural triterpene and an important intermediate of sterol and hopanoid
biosynthesis in various types of cell from bacteria to human. Synthesis and further …

Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery

A Angelova, B Angelov, R Mutafchieva… - Accounts of chemical …, 2011 - ACS Publications
Lipids and lipopolymers self-assembled into biocompatible nano-and mesostructured
functional materials offer many potential applications in medicine and diagnostics. In this …