Current progress on antioxidants incorporating the pyrazole core

VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

Synthesis and Reactivity of Electron-Deficient 3-Vinylchromones

VY Sosnovskikh - SynOpen, 2021 - thieme-connect.com
The reported methods and data for the synthesis and reactivity of electron-deficient 3-
vinylchromones containing electron-withdrawing groups at the exo-cyclic double bond are …

One-pot and two-pot synthesis of chalcone based mono and bis-pyrazolines

S Farooq, Z Ngaini - Tetrahedron Letters, 2020 - Elsevier
Pyrazoline is an important heterocyclic compound in organic and pharmaceutical industry.
The pyrazoline-based compounds are intensively used in medicines and agricultural …

[HTML][HTML] Synthesis, spectroscopic, quantum, thermal and kinetics, antibacterial and antifungal studies: Novel Schiff base 5-methyl-3-((5-bromosalicylidene) amino) …

P Devi, K Singh, B Kubavat - Results in Chemistry, 2023 - Elsevier
A novel Schiff base named 5-methyl-3-((5-bromosalicylidene) amino)-pyrazole (HMBP) was
synthesized by refluxing of 3-amino-5-methylpyrazole and 5-bromosalicylaldehyde in 1: 1 M …

Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study

S Rocha, M Lucas, VLM Silva, PMO Gomes… - International Journal of …, 2021 - Elsevier
Type 2 diabetes mellitus (DM) is a complex chronic disorder and a major global health
problem. Insulin resistance is the primary detectable abnormality and the main characteristic …

Boulton-Katritzky rearrangement of 5-substituted phenyl-3-[2-(morpholin-1-yl) ethyl]-1, 2, 4-oxadiazoles as a synthetic path to spiropyrazoline benzoates and chloride …

L Kayukova, A Vologzhanina, K Praliyev… - Molecules, 2021 - mdpi.com
The analysis of stability of biologically active compounds requires an accurate determination
of their structure. We have found that 5-aryl-3-(2-aminoethyl)-1, 2, 4-oxadiazoles are …

Styrylpyrazoles: Properties, synthesis and transformations

PMO Gomes, PMS Ouro, AMS Silva, VLM Silva - Molecules, 2020 - mdpi.com
The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged
scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number …

Nobiletin a biologically active phytoconstituent: Systematic review

AP Singh, JB Kandpal, RK Sharma… - Journal of Biologically …, 2021 - Taylor & Francis
Nobiletin is an abundant phytoconstituent having multiple pharmacological activities.
Various citrus species like orange (Citrus sinensis), lemon (Citrus limon), grapefruit (Citrus …

Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno[3,2-c]pyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and …

T Dai, Q Li, X Zhang, C Yang - The Journal of Organic Chemistry, 2019 - ACS Publications
A facile and efficient synthetic strategy for the chemoselective synthesis of
monocyclic/tricyclic-fused pyrazoles was developed, and it was oriented by different 3 …

Synthesis of 2, 3-heterofused chromones, hetero analogues of xanthone

VY Sosnovskikh - Russian Chemical Bulletin, 2022 - Springer
The review is devoted to 2, 3-heteroannelated chromones. The methods of their synthesis,
unlike 2, 3-heterothiochromones, were not generalized and analyzed. The systematization …