A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies

X Jing, K Jin - Medicinal research reviews, 2020 - Wiley Online Library
As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

[HTML][HTML] Small interfering RNA for cancer treatment: overcoming hurdles in delivery

NB Charbe, ND Amnerkar, B Ramesh… - … Pharmaceutica Sinica B, 2020 - Elsevier
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug
delivery systems are based on the difference between cancer and healthy cells. Currently …

Cyclic cell-penetrating peptides as efficient intracellular drug delivery tools

SE Park, MI Sajid, K Parang, RK Tiwari - Molecular pharmaceutics, 2019 - ACS Publications
Cyclic cell-penetrating peptides are relatively a newer class of peptides that have a huge
potential for the intracellular delivery of therapeutic agents aimed at treating challenging …

Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

J Zong, SL Cobb, NR Cameron - Biomaterials science, 2017 - pubs.rsc.org
Colloidal gold solutions have been used for centuries in a wide variety of applications
including staining glass and in the colouring of ceramics. More recently, gold nanoparticles …

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

T Wang, J Hou, C Su, L Zhao, Y Shi - Journal of nanobiotechnology, 2017 - Springer
Background A targeted drug nanoparticle (NP) delivery system has shown potential as a
possible cancer treatment. Given its merits, such as its selective distribution at tumor sites …

Advances in the application of gold nanoparticles in bone tissue engineering

H Li, S Pan, P Xia, Y Chang, C Fu, W Kong… - Journal of biological …, 2020 - Springer
The materials used in bone tissue engineering (BTE) have been advancing with each
passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs) …

Cancer targeting peptides

M Kalmouni, S Al-Hosani, M Magzoub - Cellular and Molecular Life …, 2019 - Springer
Despite continuing advances in the development of biomacromolecules for therapeutic
purposes, successful application of these often large and hydrophilic molecules has been …

Amphiphilic cell-penetrating peptides containing natural and unnatural amino acids as drug delivery agents

D Salehi, S Mozaffari, K Zoghebi, S Lohan, D Mandal… - Cells, 2022 - mdpi.com
A series of cyclic peptides,[(DipR)(WR) 4],[(DipR) 2 (WR) 3],[(DipR) 3 (WR) 2],[(DipR) 4
(WR)], and [DipR] 5, and their linear counterparts containing arginine (R) as positively …

Calcium phosphate nanoparticles-based systems for siRNA delivery

X Xu, Z Li, X Zhao, L Keen, X Kong - Regenerative Biomaterials, 2016 - academic.oup.com
Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is
still a problem due to unfavorable biodistribution profiles and poor intracellular …

Cyclic and linear peptides containing alternate WW and RR residues as molecular cargo delivery tools

L Kim, S Lohan, J Moreno, K Zoghebi… - Molecular …, 2022 - ACS Publications
Cell-impermeable and negatively charged compounds' cellular uptake across the cell
membranes remains challenging. Herein, the synthesis of four linear [(WWRR) 2,(WWRR) …