Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Macrophages are a functionally heterogeneous cell population that is mainly shaped by a
variety of microenvironmental stimuli. Interferon γ (IFN-γ), interleukin-1β (IL-1β), and …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The lipoprotein HDL has two important roles: first, it promotes reverse cholesterol transport,
and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

The progression of human tuberculosis (TB) to active disease and transmission involves the
development of a caseous granuloma that cavitates and releases infectious Mycobacterium …

Recent applications of mass spectrometry technology have dramatically increased our
understanding of the proteomic diversity of high density lipoproteins (HDL). Depending on …

During infections or acute conditions high-density lipoproteins cholesterol (HDL-C) levels
decrease very rapidly and HDL particles undergo profound changes in their composition …

During infection significant alterations in lipid metabolism and lipoprotein composition occur.
Triglyceride and VLDL cholesterol levels increase, while reduced HDL cholesterol (HDL-C) …

Mycobacterium tuberculosis is an extremely successful pathogen that demonstrates the
capacity to modulate its host both at the cellular and tissue levels. At the cellular level, the …