[HTML][HTML] The challenge of HIV-1 subtype diversity
BS Taylor, ME Sobieszczyk… - … England Journal of …, 2008 - Mass Medical Soc
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …
[HTML][HTML] Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human …
NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …
involve a sophisticated array of immune response. These genetic elements may modulate …
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
B Agerer, M Koblischke, V Gudipati… - Science …, 2021 - science.org
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus
control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell …
control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell …
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a
stable latent reservoir,, primarily in resting memory CD4+ T cells,. This reservoir presents a …
stable latent reservoir,, primarily in resting memory CD4+ T cells,. This reservoir presents a …
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Y Minokoshi, YB Kim, OD Peroni, LGD Fryer, C Müller… - Nature, 2002 - nature.com
Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food
intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of …
intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of …
[HTML][HTML] Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …
and effectively evaded immune responses, its viral fitness in cell and animal models was …
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
SA Migueles, AC Laborico, WL Shupert… - Nature …, 2002 - nature.com
It is unclear why immunological control of HIV replication is incomplete in most infected
individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in …
individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in …
Diversity considerations in HIV-1 vaccine selection
Globally, human immunodeficiency virus–type 1 (HIV-1) is extraordinarily variable, and this
diversity poses a major obstacle to AIDS vaccine development. Currently, candidate …
diversity poses a major obstacle to AIDS vaccine development. Currently, candidate …
The Trojan exosome hypothesis
SJ Gould, AM Booth… - Proceedings of the …, 2003 - National Acad Sciences
We propose that retroviruses exploit a cell-encoded pathway of intercellular vesicle traffic,
exosome exchange, for both the biogenesis of retroviral particles and a low-efficiency but …
exosome exchange, for both the biogenesis of retroviral particles and a low-efficiency but …
[HTML][HTML] The causes and consequences of HIV evolution
Understanding the evolution of the human immunodeficiency virus (HIV) is crucial for
reconstructing its origin, deciphering its interaction with the immune system and developing …
reconstructing its origin, deciphering its interaction with the immune system and developing …