Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19
R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …
[HTML][HTML] Cerebral micro-structural changes in COVID-19 patients–an MRI-based 3-month follow-up study
Y Lu, X Li, D Geng, N Mei, PY Wu, CC Huang… - …, 2020 - thelancet.com
Background Increasing evidence supported the possible neuro-invasion potential of SARS-
CoV-2. However, no studies were conducted to explore the existence of the micro-structural …
CoV-2. However, no studies were conducted to explore the existence of the micro-structural …
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme …
the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme …
The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains
By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …
Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major public health concern. A …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major public health concern. A …
Tripartite combination of candidate pandemic mitigation agents: vitamin D, quercetin, and estradiol manifest properties of medicinal agents for targeted mitigation of …
GV Glinsky - Biomedicines, 2020 - mdpi.com
Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed
as baits to build genomic-guided molecular maps of upstream regulatory elements, their …
as baits to build genomic-guided molecular maps of upstream regulatory elements, their …
Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2
On-going pandemic pneumonia outbreak COVID-19 has raised an urgent public health
issue worldwide impacting millions of people with a continuous increase in both morbidity …
issue worldwide impacting millions of people with a continuous increase in both morbidity …
Transmission of SARS-CoV-2 from humans to animals and potential host adaptation
Abstract SARS-CoV-2, the causative agent of the COVID-19 pandemic, can infect a wide
range of mammals. Since its spread in humans, secondary host jumps of SARS-CoV-2 from …
range of mammals. Since its spread in humans, secondary host jumps of SARS-CoV-2 from …
Is the rigidity of SARS-CoV-2 spike receptor-binding motif the hallmark for its enhanced infectivity? Insights from all-atom simulations
A Spinello, A Saltalamacchia… - The journal of physical …, 2020 - ACS Publications
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic is setting the
global health crisis of our time, causing a devastating societal and economic burden. An …
global health crisis of our time, causing a devastating societal and economic burden. An …