Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …

Apoptosis (programmed cell death) is a cellular self-destruction mechanism that is essential
for a variety of biological events, such as developmental sculpturing, tissue homeostasis …

Monomers are released from dental resin materials, and thus cause adverse biological
effects in mammalian cells. Cytotoxicity and genotoxicity of some of these methacrylates …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Patients with metastatic melanoma or multiple myeloma have a dismal prognosis because
these aggressive malignancies resist conventional treatment. A promising new oncologic …

Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much …

Mitochondria play a crucial role in regulating cell death, which is mediated by outer
membrane permeabilization in response to death triggers such as DNA damage and growth …

Transgenic mice with cardiac-restricted overexpression of secretable TNF (MHCsTNF)
develop progressive LV wall thinning and dilation accompanied by an increase in …

Background Fucoidan is a sulfated polysaccharide derived from brown algae that has been
reported to perform multiple biological activities, including antitumor activity. In this study, we …