Sex based differences in immune responses, affecting both the innate and adaptive immune
responses, contribute to differences in the pathogenesis of infectious diseases in males and …

Our understanding of the genetic basis of systemic lupus erythematosus (SLE) has been
rapidly advanced using large-scale, case–control, candidate gene studies as well as …

Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …

Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic,
epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we …

The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …

Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …

Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …

Despite recent progress in the understanding of systemic lupus erythematosus (SLE), the
striking 9: 1 female to male ratio of disease incidence remains largely unexplained. In …

There is growing evidence that preceding the diagnosis or classification of systemic lupus
erythematosus (SLE), patients undergo a preclinical phase of disease where markers of …

Genome-wide association studies and fine mapping of candidate regions have rapidly
advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE) …