Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

Background & Aims It is not clear how endoscopic screening for gastric cancer affects
incidence or mortality. We performed a systematic review and meta-analysis to evaluate the …

Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently
diagnosed malignancy and the third leading cause of cancer related death. Gastric …

Importance CDH1pathogenic variants have been estimated to confer a 40% to 70% and
56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely …

Background Loss of function variants in CDH1 are the most frequent cause of hereditary
diffuse gastric cancer. Endoscopy is regarded as insufficient for early detection due to the …

Background The clinical phenotype of CDH1 pathogenic variant carriers has mostly been
studied in families that fulfil criteria of hereditary diffuse gastric cancer (HDGC). We aimed at …

Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome
characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer …

Background Hereditary diffuse gastric cancer, generally caused by germline pathogenic
variants in CDH1, presents with early-onset signet ring cell carcinoma. Prophylactic total …

The prevalence of gastric cancer (GC) differs among regions worldwide, with the highest
occurrence in east Asia. Thus, its etiology, with respect to ethnic background, environmental …

Every year gastric cancer accounts for nearly 1 million new cases and more than 720 000
deaths worldwide. Prognosis is dismal because most patients are diagnosed with advanced …