The development of chloroquine as an antimalarial drug and the subsequent evolution of
drug-resistant Plasmodium strains had major impacts on global public health in the 20th …

In the first part of this account, the antimalarial drug artemisinin is presented, and the current
hypotheses on the mechanism of action of this endoperoxide-based drug are reviewed. The …

Background Chloroquine-resistant Plasmodium falciparum malaria is a major health
problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated in …

The emergence and spread of multidrug resistant Plasmodium falciparum has severely
limited the therapeutic options for the treatment of malaria. With ever‐increasing failure rates …

Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine
resistance in Plasmodium falciparum, was not the resistance determinant. A further analysis …

Chloroquine has been widely used for malaria treatment and prophylaxis for several
decades, but its usefulness has now declined with the emergence of chloroquine resistance …

Resistance to the antimalarial drug chloroquine has been linked with polymorphisms within
a gene termed pfcrt in the human malarial parasite Plasmodium falciparum, yet the …

Emergence of drugs resistant strains of Plasmodium falciparum has augmented the scourge
of malaria in endemic areas. Antimalaria drugs act on different intracellular targets. The …

Owing to the widespread occurrence of drug resistance, there is now an urgent need for new
antimalarial drugs. There is compelling evidence that the target of the historically most …

Chloroquine resistance has been linked to mutations in the pfcrt and pfmdr1 genes of
Plasmodium falciparum. To estimate the prevalence of the pfcrt K76T, pfmdr1 N86Y, and …