TCF1 in T cell immunity: a broadened frontier
TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …
downstream of the WNT signalling pathway and are essential for early T cell development …
Crosstalk between Wnt/β-Catenin and NF-κB signaling pathway during inflammation
B Ma, MO Hottiger - Frontiers in immunology, 2016 - frontiersin.org
Besides its important role in embryonic development and homeostatic self-renewal in adult
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …
Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy
C Gong, J Tian, Z Wang, Y Gao, X Wu, X Ding… - Journal of …, 2019 - Springer
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …
information between cells. However, Exo are limited in terms of their abilities to target …
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
N Takebe, L Miele, PJ Harris, W Jeong… - Nature reviews Clinical …, 2015 - nature.com
During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …
Understanding multicellular function and disease with human tissue-specific networks
Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
WNT signalling pathways as therapeutic targets in cancer
JN Anastas, RT Moon - Nature Reviews Cancer, 2013 - nature.com
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …
appreciation for the complex roles for WNT signalling pathways in cancer has increased …
The many faces and functions of β‐catenin
T Valenta, G Hausmann, K Basler - The EMBO journal, 2012 - embopress.org
β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …
Cross-kingdom inhibition of breast cancer growth by plant miR159
MicroRNAs (miRNAs) are critical regulators of gene expression, and exert extensive impacts
on development, physiology, and disease of eukaryotes. A high degree of parallelism is …
on development, physiology, and disease of eukaryotes. A high degree of parallelism is …
TCF/LEFs and Wnt signaling in the nucleus
KM Cadigan, ML Waterman - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …
SOX transcription factors as important regulators of neuronal and glial differentiation during nervous system development and adult neurogenesis
M Stevanovic, D Drakulic, A Lazic… - Frontiers in molecular …, 2021 - frontiersin.org
The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …
properties of both classical TFs and architectural components of chromatin. Since the …