During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

BACKGROUND The human uterine endometrium undergoes significant remodeling and
regeneration on a rapid and repeated basis, after parturition, menstruation, and in some …

Human reproduction is characterized by a high degree of embryo wastage, which is largely
ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies …

BACKGROUND The embryo implantation process is crucial for the correct establishment
and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to …

Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …

BACKGROUND Mechanisms underlying early reproductive loss in the human are beginning
to be elucidated. The migratory and invasive capacity of human endometrial stromal cells …

Endometrial cells perceive and respond to their microenvironment forming the basis of
endometrial homeostasis. Errors in endometrial cell signaling are responsible for a wide …

Abstract Three-dimensional (3D) in vitro models have been established to study the
physiology and pathophysiology of the endometrium. With emerging evidence that the …

HB-EGF is a member of the EGF family of ligands that is initially synthesized as a membrane-
bound growth factor termed, proHB-EGF. The membrane bound proHB-EGF undergoes …