Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Clopidogrel, a P2Y12 inhibitor, is a novel anti-fibrosis agent for chronic kidney disease
(CKD), but its mechanisms remain unclear, which we investigated by silencing P2Y12 or …

Historically, the control of renal vascular and tubular function has, for the most part,
concentrated on neural and endocrine regulation. However, in addition to these extrinsic …

Abstract P2Y 12 receptor (P2Y 12-R) signaling is mediated through G i, ultimately reducing
cellular cAMP levels. Because cAMP is a central modulator of arginine vasopressin (AVP) …

Studies have demonstrated separately that hypertension is associated with platelet
activation in the periphery (resulting in accumulation and localized inflammatory response) …

Focal segmental glomerulosclerosis (FSGS) is a glomerular lesion often associated with
nephrotic syndrome. It is also associated with a high risk of progression to end-stage kidney …

Background: Angiotensin II (AngII) induces renal fibrosis, characterized by fibroblast
proliferation, inflammatory cell infiltration and excessive extracellular matrix deposition, all of …

We have previously shown that hypertensive female rats have more regulatory T cells
(Tregs), which contribute more to blood pressure (BP) control in female versus male rats …

Ticagrelor has been reported to decrease cardiovascular mortality compared with
clopidogrel. This benefit cannot be fully explained by the more efficient platelet inhibition …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …