The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Eukaryotes associate their genomes with histone proteins, forming nucleosome particles.
Nucleosomes regulate and protect the genetic information. They often assemble into evenly …

Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …

Enhancer-mediated gene activation generally requires physical proximity between
enhancers and their target gene promoters. However, the molecular mechanisms by which …

The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …

Loss of H2A–H2B histone dimers is a hallmark of actively transcribed genes, but how the
cellular machinery functions in the context of noncanonical nucleosomal particles remains …

The critical role of the INO80 chromatin remodeling complex in transcription is commonly
attributed to its nucleosome sliding activity. Here, we have found that INO80 prefers to …

Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by
alignment to reference sites like active promoters. How the distances between nucleosomes …

Introduction Podocyte senescence causes podocyte loss and glomerulopathy. Excessive
fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes …

Eukaryotic cells are thought to arrange nucleosomes into extended arrays with evenly
spaced nucleosomes phased at genomic landmarks. Here we tested to what extent this …