Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Since the 1960s, paediatric oncologists have gradually become better organised in large
study groups and participation in clinical trials is today considered as the standard of care …

ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

MAPPYACTS (NCT02613962) is an international prospective precision medicine trial
aiming to define tumor molecular profiles in pediatric patients with recurrent/refractory …

Background Accurate childhood cancer burden data are crucial for resource planning and
health policy prioritisation. Model-based estimates are necessary because cancer …

Background Despite the substantial burden caused by childhood cancer globally, childhood
cancer incidence obtained in a nationwide childhood cancer registry and the accessibility of …

Background Worldwide data for cancer survival are scarce. We aimed to initiate worldwide
surveillance of cancer survival by central analysis of population-based registry data, as a …

Ependymal tumors across age groups are currently classified and graded solely by
histopathology. It is, however, commonly accepted that this classification scheme has limited …

Male patients with childhood, adolescent, and young adult cancer are at an increased risk
for infertility if their treatment adversely affects reproductive organ function. Future fertility is a …

Background Immunotherapy with the chimeric anti-GD2 monoclonal antibody dinutuximab,
combined with alternating granulocyte-macrophage colony-stimulating factor and …