Both safety and efficacy of medical treatment can vary depending on the ethnogeographic
background of the patient. One of the reasons underlying this variability is differences in …

Azathioprine (AZA) is a well-known immunosuppressant used for many years for its ability to
ensure long term disease remission in inflammatory bowel diseases (IBD) at an affordable …

Azathioprine (AZA) is the most common immunosuppressive drug used to treat myasthenia
gravis (MG). To analyses the prevalence of thiopurine S-methyl-transferase (TPMT) …

Introduction: Genetic variation in the thiopurine S-methyltransferase (TPMT) gene by and
large predicts variability in 6-mercaptopurine (6-MP) related toxicities. However, some …

Background: 6-mercaptopurine usage is associated with myelotoxicity and increased risk in
patients carrying metabolism-related genetic variations. This study aimed to determine the …

Objectives This study assessed the activity of thiopurine S-methyltransferase (TPMT) in
Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well …

The Nigerian population exhibits huge ethnic and genetic diversity, typical of African
populations, which can be harnessed for improved drug-response and disease …

The landscape of genetic testing has changed vastly over the past decade with the advent of
more widely available direct-to-consumer (DTC) testing kits. With more widely accessible …

Aim: The paper aims to present a comprehensive summary of state-of-the-art knowledge on
race-related differences which may be of great importance for patient management in …

Introduction: The human species shows a great variability. The differences involve culture,
customs, appearance but they also come to include some biological or physiological …