The yeast deletion collection: a decade of functional genomics
The yeast deletion collections comprise> 21,000 mutant strains that carry precise start-to-
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
Strategies for target identification of antimicrobial natural products
Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …
pharmaceutical companies over the last two decades, natural products have undeniably …
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a
series of quality control events including ribosome rescue, degradation of the stalled …
series of quality control events including ribosome rescue, degradation of the stalled …
Accurate classification of protein subcellular localization from high-throughput microscopy images using deep learning
T Pärnamaa, L Parts - G3: Genes, Genomes, Genetics, 2017 - academic.oup.com
High-throughput microscopy of many single cells generates high-dimensional data that are
far from straightforward to analyze. One important problem is automatically detecting the …
far from straightforward to analyze. One important problem is automatically detecting the …
Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation
Key protein adapters couple translation to mRNA decay on specific classes of problematic
mRNAs in eukaryotes. Slow decoding on non-optimal codons leads to codon-optimality …
mRNAs in eukaryotes. Slow decoding on non-optimal codons leads to codon-optimality …
Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila
ML Urbanus, AT Quaile, PJ Stogios… - Molecular systems …, 2016 - embopress.org
Pathogens deliver complex arsenals of translocated effector proteins to host cells during
infection, but the extent to which these proteins are regulated once inside the eukaryotic cell …
infection, but the extent to which these proteins are regulated once inside the eukaryotic cell …
The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress
Most mitochondrial proteins are synthesized as precursors in the cytosol and post-
translationally transported into mitochondria. The mitochondrial surface protein Tom70 acts …
translationally transported into mitochondria. The mitochondrial surface protein Tom70 acts …
FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
Alzheimer's disease (AD) is defined by progressive neurodegeneration, with oligomerization
and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in its pathogenesis. In …
and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in its pathogenesis. In …
Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells
Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown
functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent …
functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent …
Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples
CE O'Brien, J Oliveira-Pacheco, E Ó Cinnéide… - PLoS …, 2021 - journals.plos.org
Candida tropicalis is a human pathogen that primarily infects the immunocompromised.
Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in …
Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in …