The past two decades have witnessed an explosion in the identification, largely by positional
cloning, of genes associated with mendelian diseases. The roughly 1,200 genes that have …

The Human Genome Project in the United States is now well underway. Its programmatic
direction was largely set by a National Research Council report issued in 1988. The broad …

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning
of the cystic fibrosis gene and definition of its protein product. In the absence of direct …

Abstract Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder
characterized by neurodegeneration of the cerebellum, spinal cord and brainstem. A 1.2 …

The CD44 molecule is known to display extensive size heterogeneity, which has been
attributed both to alternative splicing and to differential glycosylation within the extracellular …

Recurring chromosomal translocations involving chromosome 11, band q23, have been
observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We …

We constructed two megabase-sized YACs containing large contiguous fragments of the
human heavy and kappa (κ) light chain immunoglobulin (Ig) loci in nearly germline …

NA REPORT ISSUED IN JANUARY 1988, THE NATIONAL RE-search Council (NRC)
Committee on the Mapping and Sequencing of the Human Genome, on which the present …

Translocations involving the IgH locus at chromosomal locus 14q32. 3 are a common event
in many B-cell malignancies. The translocations, which generally occur into JH and switch …

Some acute lymphocytic leukaemias, particularly those in young children, are associated
with at (4; 11)(q21; q23) reciprocal translocation. We have cloned the translocation …