The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

The classification of idiopathic inflammatory myopathies (IIM) is based on clinical,
serological and histological criteria. The identification of myositis‐specific antibodies has …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

Pathogens use virulence factors to inhibit the immune system. The guard hypothesis,
postulates that hosts monitor (or 'guard') critical innate immune pathways such that their …

Autophagy is a conserved process that delivers cytosolic substances to the lysosome for
degradation, but its direct role in the regulation of antiviral innate immunity remains poorly …

Anti-transcription intermediary factor 1 (TIF1)-γ autoantibodies are robustly linked with
cancer-associated DM in adults. This review aims to give an overview of the physiological …

Autoimmune myopathies (myositides) are strongly associated with malignancy. The link
between myositis and cancer, originally noticed by Bohan and Peter in their classification in …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterised by
myofibroblast proliferation and abnormal extracellular matrix accumulation in the lungs …

DNA G-quadruplexes (G4s) are known to be an integral part of the complex regulatory
systems in both normal and pathological cells. At the same time, the ability of G4s to impede …

Transcriptional intermediary factor 1 γ (TIF1γ), also known as TRIM33, RFG7, PTC7, or
Ectodermin, is an E3 ubiquitin-ligase family member with a ring-box-coiled-coil region. It can …