[HTML][HTML] Luteolin, a flavonoid, as an anticancer agent: A review

M Imran, A Rauf, T Abu-Izneid, M Nadeem… - Biomedicine & …, 2019 - Elsevier
Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-
cancer compounds. Luteolin (3, 4, 5, 7-tetrahydroxy flavone) is a flavonoid found in different …

[HTML][HTML] Phenolic compounds in Lycium berry: Composition, health benefits and industrial applications

Y Jiang, Z Fang, W Leonard, P Zhang - Journal of Functional Foods, 2021 - Elsevier
This review provides a comprehensive summary of phenolic compounds in Lycium berry,
focusing on their composition, functionalities, potential health benefits, industrial …

HO‐1 contributes to luteolin‐triggered ferroptosis in clear cell renal cell carcinoma via increasing the labile iron pool and promoting lipid peroxidation

S Han, F Lin, Y Qi, C Liu, L Zhou, Y Xia… - Oxidative Medicine …, 2022 - Wiley Online Library
Ferroptosis, a novel form of regulated cell death characterized by disrupted iron metabolism
and the accumulation of lipid peroxides, has exhibited enormous potential in the therapy of …

Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives

MF Manzoor, N Ahmad, Z Ahmed… - Journal of Food …, 2019 - Wiley Online Library
Abstract Luteolin is a 3′, 4′, 5, 7 tetra hydroxyl flavonoid that exits in many plants, fruits,
and vegetable. Many methods of extraction, isolation, and purification are being used, and …

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy

X Dai, J Zhang, F Arfuso… - Experimental …, 2015 - journals.sagepub.com
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to
selectively induce apoptotic cell death in various tumor cells by engaging its death-inducing …

Molecular targets of luteolin in cancer

MJ Tuorkey - European Journal of Cancer Prevention, 2016 - journals.lww.com
Many food-derived phytochemical compounds and their derivatives represent a cornucopia
of new anticancer compounds. Despite extensive study of luteolin, the literature has no …

Metabolic fate of luteolin in rats: its relationship to anti-inflammatory effect

A Kure, K Nakagawa, M Kondo, S Kato… - Journal of Agricultural …, 2016 - ACS Publications
Luteolin is a naturally occurring flavone that reportedly has anti-inflammatory effects.
Because most luteolin is conjugated following intestinal absorption, free luteolin is likely …

Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms

EM Bajalia, FB Azzouz, DA Chism, DM Giansiracusa… - Cancers, 2022 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most frequently diagnosed kidney
cancer. Once RCC metastasizes, successful treatment is difficult to achieve. There is an …

TRAIL-sensitizing effects of flavonoids in cancer

A Luiz-Ferreira, T Pacifico, ÁC Cruz, F Laudisi… - International Journal of …, 2023 - mdpi.com
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) represents a promising
anticancer agent, as it selectively induces apoptosis in transformed cells without altering the …

Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

S Song, Z Su, H Xu, M Niu, X Chen, H Min… - Cell death & …, 2017 - nature.com
The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been
fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC cells …