RNA helicases from the DEAD-box family are found in almost all organisms and have
important roles in RNA metabolism. They are associated with many processes ranging from …

RNA helicases of the DEAD box and related DExD/H proteins form a very large superfamily
of proteins conserved from bacteria and viruses to humans. They have seven to eight …

ATSAS is a comprehensive software suite for the analysis of small-angle scattering data
from dilute solutions of biological macromolecules or nanoparticles. It contains applications …

Hepatitis C virus (HCV) causes acute and chronic liver disease in humans, including chronic
hepatitis, cirrhosis, and hepatocellular carcinoma. Studies of this virus have been hampered …

We have determined two different structures of PcrA DNA helicase complexed with the same
single strand tailed DNA duplex, providing snapshots of different steps on the catalytic …

Structural information on helicase proteins has expanded recently beyond the DNA
helicases Rep and PcrA, and the hepatitis C virus RNA helicase to include UvrB, members …

Members of the RNA-helicase family are defined by several evolutionary conserved motifs.
They are found in all organisms–from bacteria to humans–and many viruses. The minimum …

Hepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the
advent of diagnostic tests for hepatitis A and B virus infection (A LTER et al. 1975; P RINCE …

ABSTRACT NS3 protein of dengue virus type 2 has a serine protease domain within the N-
terminal 180 residues. NS2B is required for NS3 to form an active protease involved in …

Abstract Background: Hepatitis C virus (HCV) currently infects approximately 3% of the
world's population. HCV RNA is translated into a polyprotein that during maturation is …