Abstract Fluorouracil (5-FU) is one of the most efficient chemotherapy drugs for the treatment
of different malignancies, yet many patients encounter chemotherapy failure owing to the …

Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various
solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs …

In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to
reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors …

Dihydropyrimidine dehydrogenase (DPD; DPYD gene) variants have emerged as reliable
predictors of adverse toxicity to the chemotherapy agent 5‐fluorouracil (5‐FU). The intronic …

The 5-year survival rate of pancreatic ductal carcinoma (PDAC) patients is< 10% despite
progress in clinical medicine. Strategies to prevent the development of PDAC are urgently …

Wang C, Li X, Zhang J, Ge Z, Chen H, Hu J. Onco Targets Ther. 2018; 11: 7853–7864. We,
the Editors and Publisher of OncoTargets and Therapy, have retracted the published article …

Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration
in colorectal tumors has been recognized recently as an important pathophysiologic event …

Chemotherapy was the main treatment method for esophageal cancer (EC) patients.
However, chemotherapy resistance due to multiple factors is a major barrier to EC treatment …

Background Emerging evidence reveals the vital role of enhancer of zeste homolog 2
(EZH2) in cancer chemoresistance. However, its function and molecular mechanisms in …

Simple Summary Fluoropyrimidines represent the backbone of many combination
chemotherapy regimens for the treatment of solid cancers but are still associated with toxicity …