Optogenetic engineering for ion channel modulation
Optogenetics, which integrates photonics and genetic engineering to control protein activity
and cellular processes, has transformed biomedical research. Its precise spatiotemporal …
and cellular processes, has transformed biomedical research. Its precise spatiotemporal …
Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A)
R Barzan, B Bozkurt, MM Nejad, ST Süß… - Nature …, 2024 - nature.com
Response gain is a crucial means by which modulatory systems control the impact of
sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such …
sensory input. In the visual cortex, the serotonergic 5-HT2A receptor is key in such …
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
J Wietek, A Nozownik, M Pulin, I Saraf-Sinik… - Nature …, 2024 - nature.com
Abstract Information is transmitted between brain regions through the release of
neurotransmitters from long-range projecting axons. Understanding how the activity of such …
neurotransmitters from long-range projecting axons. Understanding how the activity of such …