Histone variants: emerging players in cancer biology
C Vardabasso, D Hasson, K Ratnakumar… - Cellular and molecular …, 2014 - Springer
Histone variants are key players in shaping chromatin structure, and, thus, in regulating
fundamental cellular processes such as chromosome segregation and gene expression …
fundamental cellular processes such as chromosome segregation and gene expression …
Epigenetic changes in cancer
CA Iacobuzio-Donahue - Annual Review of Pathology …, 2009 - annualreviews.org
Cancer is as much an epigenetic disease as it is a genetic disease, and epigenetic
alterations in cancer often serve as potent surrogates for genetic mutations. Normal …
alterations in cancer often serve as potent surrogates for genetic mutations. Normal …
The birth of the Epitranscriptome: deciphering the function of RNA modifications
Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …
Chromatin regulatory mechanisms in pluripotency
JA Lessard, GR Crabtree - Annual review of cell and …, 2010 - annualreviews.org
Stem cells of all types are characterized by a stable, heritable state permissive of multiple
developmental pathways. The past five years have seen remarkable advances in …
developmental pathways. The past five years have seen remarkable advances in …
RNA editing-dependent epitranscriptome diversity in cancer stem cells
Cancer stem cells (CSCs) can regenerate all facets of a tumour as a result of their stem cell-
like capacity to self-renew, survive and become dormant in protective microenvironments …
like capacity to self-renew, survive and become dormant in protective microenvironments …
Circulating histones to detect and monitor the progression of cancer
Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring
method, which could identify cancer-related alterations in nucleosome or histone levels and …
method, which could identify cancer-related alterations in nucleosome or histone levels and …
Histone variant macroH2A confers resistance to nuclear reprogramming
How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is
poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes …
poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes …
Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency
How cell fate becomes restricted during somatic cell differentiation is a long-lasting question
in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during …
in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during …
[HTML][HTML] Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions
C Yang, Y Yang, L Brennan, EE Bouhassira… - The FASEB …, 2010 - ncbi.nlm.nih.gov
The eye lens is an encapsulated avascular organ whose function is to focus light on the
retina. Lens comprises a single progenitor cell lineage in multiple states of differentiation …
retina. Lens comprises a single progenitor cell lineage in multiple states of differentiation …
MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
C Creppe, P Janich, N Cantariño… - … and cellular biology, 2012 - Taylor & Francis
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is
the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we …
the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we …