Heart disease causing cardiac cell death due to ischemia–reperfusion injury is a major
cause of morbidity and mortality in the United States. Coronary heart disease and …

This review focuses on autoimmune myocarditis and its sequela, inflammatory dilated
cardiomyopathy (DCMI), and the inflammatory and immune mechanisms underlying the …

Background—Antibodies to the β1-adrenergic receptor (β1AR) are detected in a substantial
number of patients with idiopathic dilated cardiomyopathy (DCM). The mechanism whereby …

Autoimmune sensorineural hearing loss (ASNHL) is characterized typically by bilateral,
rapidly progressive hearing loss that responds therapeutically to corticosteroid treatment …

Influenza is a contagious, acute respiratory disease that is a major cause of morbidity and
mortality throughout the world. CD4 T cells play an important role in the immune response to …

BACKGROUND: The pathophysiology of interstitial cystitis (IC) is unknown. Deficits in
urothelial cell layers and autoimmune mechanisms may play a role. OBJECTIVE: To …

OBJECTIVE To examine bladder function in a newly developed experimental autoimmune
cystitis (EAC) model in female SWXJ strain mice, as a potential animal model for interstitial …

Animal models that mimic cardiovascular diseases are indispensable tools for
understanding the mechanisms underlying the diseases at the cellular and molecular level …

The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is enigmatic.
Autoimmunity and impaired urothelium might lead the underlying pathology. A major …

The pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is poorly
understood. Inflammatory and autoimmune mechanisms may play a role. We developed a …