A comprehensive overview of liquid biopsy applications in pediatric solid tumors

FW Janssen, NSM Lak, CY Janda, LA Kester… - NPJ precision …, 2024 - nature.com
Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with
potential applications during all stages of patient care, from diagnosis to long-term follow-up …

[HTML][HTML] Molecular biomarkers with potential clinical application in testicular cancer

J Lobo, AM Acosta, GJ Netto - Modern Pathology, 2023 - Elsevier
Testicular germ cell tumors (TGCTs) and sex cord-stromal tumors (SCSTs) are the most
common testicular neoplasms. The morphological spectrum of such tumors is wide, with …

MiRNA biomarkers in cancers of the male reproductive system: are we approaching clinical application?

V Constâncio, NT Tavares, R Henrique… - …, 2023 - Wiley Online Library
Background Specific cancer types face specific clinical management challenges. Owing to
their stability, robustness and fast, easy and cost‐effective detection, microRNAs (miRNAs) …

Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium

A Fonseca, J Lobo, FK Hazard, J Gell… - British journal of …, 2022 - nature.com
Germ cell tumours (GCTs) are a heterogeneous group of rare neoplasms that present in
different anatomical sites and across a wide spectrum of patient ages from birth through to …

Combining Hypermethylated RASSF1A Detection Using ddPCR with miR-371a-3p Testing: An Improved Panel of Liquid Biopsy Biomarkers for Testicular Germ Cell …

J Lobo, LMJ van Zogchel, MG Nuru, AJM Gillis… - Cancers, 2021 - mdpi.com
Simple Summary Testicular germ cell tumors are the most common solid cancers in men
aged between 15–39 years. There is a need of non-invasive biomarkers for diagnosis and …

Circulating microRNAs for detection of germ cell tumours: a narrative review

CD Fankhauser, MM Nuño, MJ Murray, L Frazier… - European Urology …, 2022 - Elsevier
Testicular germ cell tumours (GCTs) are the most common malignancy among young men.
Management of GCTs relies on the serum tumour markers α-fetoprotein, human chorionic …

Children's Oncology Group's 2023 blueprint for research: Germ cell tumors

R Bhuta, R Shah, JJ Gell, JN Poynter… - Pediatric blood & …, 2023 - Wiley Online Library
Extracranial germ cell tumors (GCT) are a biologically diverse group of tumors occurring in
children, adolescents, and young adults. The majority of patients have excellent outcomes …

A stroll through the present and future of testicular germ cell tumour biomarkers

NT Tavares, R Henrique, A Bagrodia… - Expert Review of …, 2023 - Taylor & Francis
Introduction Testicular germ cell tumors (TGCT) are the most commonly diagnosed cancers
among young men. Although these tumors usually have a good prognosis and are highly …

Testicular germ cell tumour cells release microRNA‐containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour …

L Alonso‐Crisostomo, J Trendell… - … Journal of Cancer, 2024 - Wiley Online Library
Malignant germ‐cell‐tumours (GCTs) are characterised by microRNA (miRNA/miR‐)
dysregulation, with universal over‐expression of miR‐371~ 373 and miR‐302/367 clusters …

[HTML][HTML] Assessing the risk to develop a growing teratoma syndrome based on molecular and epigenetic subtyping as well as novel secreted biomarkers

P Pongratanakul, F Bremmer, S Pauls, G Poschmann… - Cancer Letters, 2024 - Elsevier
In germ cell tumors (GCT), a growing teratoma during chemotherapy with decreasing tumor
markers was defined as 'growing teratoma syndrome'(GTS) by Logothetis et al. in 1982. So …