Alternative splicing is the process of producing variably spliced mRNAs by choosing distinct
combinations of splice sites within a messenger RNA precursor. This splicing enables …

Alternative splicing of pre-mRNAs is a fundamental step in RNA processing required for
gene expression in most metazoans. Serine and arginine-rich proteins (SR proteins) …

Summary N 6-methyladenosine (m 6 A) methyltransferase Mettl3 is involved in conventional
T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we …

Background Ovarian folliculogenesis is a tightly regulated process leading to the formation
of functional oocytes and involving successive quality control mechanisms that monitor …

Efficient immune responses rely on the proper differentiation of CD8+ T cells into effector
and memory cells. Here, we show a critical requirement of N 6-Methyladenosine (m 6 A) …

Long non-coding RNAs (lncRNAs) have been implicated in dilated cardiomyopathy (DCM).
However, the biological functions and regulatory mechanisms of lncRNAs in DCM remain …

RNA splicing dysregulation and the involvement of specific splicing factors are emerging as
common factors in both obesity and metabolic disorders. The study provides compelling …

Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Despite
ongoing efforts, there remains a dearth of targeted drugs capable of effectively inhibiting …

T cell factor 1 (Tcf1) is known as a critical mediator for natural killer (NK) cell development
and terminal maturation. However, its essential targets and precise mechanisms involved in …

Alternative splicing (AS) participates in tumor development and tumor microenvironment
formation. However, the landscape of immune-infiltrating AS events in pan-cancer and …