The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine
(decitabine) are the currently most advanced drugs for epigenetic cancer therapies. These …

Antiviral drug discovery is becoming increasingly important due to the global threat of viral
disease pandemics. Many members of the genus Flavivirus are significant human …

Hydrophilic purine and pyrimidine nucleosides rely on specialized carrier proteins for their
membrane translocation. The recent identification of two gene families encoding …

Nucleoside analogs are important components of treatment regimens for various
malignancies. Nucleoside-specific membrane transporters mediate plasma membrane …

The fundamental role of altered epigenetic modification patterns in tumorigenesis
establishes epigenetic regulatory enzymes as important targets for cancer therapy. Over the …

Replicating cells undergo DNA synthesis in the highly regulated, S-phase of the cell cycle.
Analogues of the pyrimidine deoxynucleoside thymidine may be inserted into replicating …

Concentrative nucleoside transporters (CNT; SLC28) and equilibrative nucleoside
transporters (ENT; SLC29) mediate the uptake of natural nucleosides and a variety of …

In patients infected by HIV, the efficacy of highly active antiretroviral (ARV) therapy through
the blockade of different steps of the retrovirus life cycle is now well established. As HIV is a …

A broad range of nanomedicines is being developed to improve drug delivery for CNS
disorders. The structure of the blood–brain barrier (BBB), the presence of efflux pumps and …

Up until the early 2000s, a functional role for microRNAs (miRNAs) was yet to be elucidated.
With the advent of increasingly high-throughput and precise RNA-sequencing techniques …