The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …

Histone deacetylases (HDACs) are enzymes that play a key role in the epigenetic regulation
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …

Expression of PD-1 ligands by tumors and interaction with PD-1–expressing T cells in the
tumor microenvironment can result in tolerance. Therapies targeting this coinhibitory axis …

Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have
enormous therapeutic potential and have pleiotropic effects at the cellular and systemic …

The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52463182&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Histone deacetylases (HDACs) are involved in diverse cellular regulatory mechanisms
including non-canonical functions outside the chromatin environment. Several publications …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

Epigenetic modifications, like histone acetylation, are essential for regulating gene
expression within cells. Cancer cells acquire pathological epigenetic modifications resulting …

Checkpoint inhibitor therapy has led to major treatment advances for several cancers
including non-small cell lung cancer (NSCLC). Despite this, a significant percentage of …