Hedgehog/GLI signaling pathway: transduction, regulation, and implications for disease
AN Sigafoos, BD Paradise, ME Fernandez-Zapico - Cancers, 2021 - mdpi.com
Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …
development and it is commonly dysregulated in many diseases, including cancer. This …
RNA polymerase II pausing in development: orchestrating transcription
A Abuhashem, V Garg… - Open Biology, 2022 - royalsocietypublishing.org
The coordinated regulation of transcriptional networks underpins cellular identity and
developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) …
developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) …
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
CM Olson, B Jiang, MA Erb, Y Liang, ZM Doctor… - Nature chemical …, 2018 - nature.com
Abstract Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional
elongation, is a promising target for cancer therapy, particularly for cancers driven by …
elongation, is a promising target for cancer therapy, particularly for cancers driven by …
Multiplexed gene control reveals rapid mRNA turnover
A Baudrimont, S Voegeli, EC Viloria, F Stritt… - Science …, 2017 - science.org
The rates of mRNA synthesis and decay determine the mRNA expression level. The two
processes are under coordinated control, which makes the measurements of these rates …
processes are under coordinated control, which makes the measurements of these rates …
The histone deacetylase SIRT6 restrains transcription elongation via promoter-proximal pausing
JP Etchegaray, L Zhong, C Li, T Henriques, E Ablondi… - Molecular cell, 2019 - cell.com
Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein
transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward …
transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward …
[HTML][HTML] Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation
Y Zhang, A Dakic, R Chen, Y Dai, R Schlegel, X Liu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Human Papillomavirus Viruses (HPVs) are associated with the majority of human
cervical and anal cancers and 10-30% of head and neck squamous carcinomas. E6 …
cervical and anal cancers and 10-30% of head and neck squamous carcinomas. E6 …
A novel lnc-PCF promotes the proliferation of TGF-β1-activated epithelial cells by targeting miR-344a-5p to regulate map3k11 in pulmonary fibrosis
H Liu, B Wang, J Zhang, S Zhang, Y Wang… - Cell death & …, 2017 - nature.com
Emerging evidence suggests that microRNA (miRNA) and long noncoding RNA (lncRNA)
play important roles in disease development. However, the mechanism underlying mRNA …
play important roles in disease development. However, the mechanism underlying mRNA …
[HTML][HTML] The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression
Calcium influx into cells via plasma membrane protein channels is tightly regulated to
maintain cellular homeostasis. Calcium channel proteins in the plasma membrane and …
maintain cellular homeostasis. Calcium channel proteins in the plasma membrane and …
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl …
J Shan, F Zhang, J Sharkey, TA Tang… - Nucleic Acids …, 2016 - academic.oup.com
The response to amino acid (AA) limitation of the entire aminoacyl-tRNA synthetase (ARS)
gene family revealed that 16/20 of the genes encoding cytoplasmic-localized enzymes are …
gene family revealed that 16/20 of the genes encoding cytoplasmic-localized enzymes are …
RNA polymerase II pausing as a context-dependent reader of the genome
A Scheidegger, S Nechaev - Biochemistry and Cell Biology, 2016 - cdnsciencepub.com
The RNA polymerase II (Pol II) transcribes all mRNA genes in eukaryotes and is among the
most highly regulated enzymes in the cell. The classic model of mRNA gene regulation …
most highly regulated enzymes in the cell. The classic model of mRNA gene regulation …