Moderate‐to‐severe pain represents a heavy burden in patients' quality of life, and
ultimately in the society and in healthcare costs. The aim of this review was to summarize …

This study was designed to demonstrate the histopathological and biochemical changes in
rat cerebral cortex and testicles due to chronic usage of tramadol and the effect of …

Background: Tramadol is becoming abused among teens, especially between males. The
study aimed to investigate the histopathological and biochemical profiles of acute and …

Tramadol and tapentadol are extensively prescribed for the treatment of moderate to severe
pain. Although these drugs are very effective in pain treatment, the number of intoxications …

Tramadol, one of the most commonly abused drugs in Middle East, impacts
spermatogenesis and disturbs reproductive hormones in animal studies. We aimed to …

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely
prescribed due to the enhanced therapeutic profiles resulting from the synergistic …

Tramadol and tapentadol are fully synthetic and extensively used analgesic opioids,
presenting enhanced therapeutic and safety profiles as compared with their peers. However …

Tramadol and tapentadol are two atypical synthetic opioid analgesics, with monoamine
reuptake inhibition properties. Mainly aimed at the treatment of moderate to severe pain …

Epimedium brevicornum Maxim (EbM) is a well-known Chinese herb that has been widely
used for the treatment of several diseases. The main purpose of this study is to examine the …

Aim: The present study aimed to elucidate the effects of tramadol on the testicular functions
of adult male rats due to the chronic usage of tramadol and the effect of its withdrawal …