The role of adult hippocampal neurogenesis in brain health and disease

T Toda, SL Parylak, SB Linker, FH Gage - Molecular psychiatry, 2019 - nature.com
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood

C Anacker, R Hen - Nature Reviews Neuroscience, 2017 - nature.com
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Regulation and function of adult neurogenesis: from genes to cognition

JB Aimone, Y Li, SW Lee… - Physiological …, 2014 - journals.physiology.org
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis

CA Denny, MA Kheirbek, EL Alba, KF Tanaka… - Neuron, 2014 - cell.com
Memory traces are believed to be ensembles of cells used to store memories. To visualize
memory traces, we created a transgenic line that allows for the comparison between cells …

Distinct contribution of adult-born hippocampal granule cells to context encoding

NB Danielson, P Kaifosh, JD Zaremba, M Lovett-Barron… - Neuron, 2016 - cell.com
Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it
remains unknown how these cells behave in vivo. Here, we have used two-photon calcium …

[HTML][HTML] Probing and regulating dysfunctional circuits using deep brain stimulation

AM Lozano, N Lipsman - Neuron, 2013 - cell.com
Despite the best available medical treatments, many patients continue to be disabled by
neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging …

Recalibrating the relevance of adult neurogenesis

JS Snyder - Trends in neurosciences, 2019 - cell.com
Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …

Functions and dysfunctions of adult hippocampal neurogenesis

KM Christian, H Song, G Ming - Annual review of neuroscience, 2014 - annualreviews.org
Adult neurogenesis, a developmental process of generating functionally integrated neurons,
occurs throughout life in the hippocampus of the mammalian brain and showcases the …

Functions of adult-born neurons in hippocampal memory interference and indexing

SM Miller, A Sahay - Nature neuroscience, 2019 - nature.com
The dentate gyrus–CA3 circuit of the hippocampus is continuously modified by the
integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged …

[PDF][PDF] An integrated approach to neuro-development, neuroplasticity and cognitive improvement

AS Drigas, M Karyotaki, C Skianis - International Journal of Recent …, 2018 - academia.edu
Plasticity is a basic process that underlies neural and cognitive functioning, unraveling thus
the former's pervasive role in development and learning. Plasticity processes operate in both …