Causes and consequences of micronuclei

K Krupina, A Goginashvili, DW Cleveland - Current opinion in cell biology, 2021 - Elsevier
Micronuclei are small membrane-bounded compartments with a DNA content encapsulated
by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have …

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

X Guo, J Ni, Z Liang, J Xue, MF Fenech… - … Research/Reviews in …, 2019 - Elsevier
Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

Delete and survive: strategies of programmed genetic material elimination in eukaryotes

D Dedukh, A Krasikova - Biological Reviews, 2022 - Wiley Online Library
Genome stability is a crucial feature of eukaryotic organisms because its alteration
drastically affects the normal development and survival of cells and the organism as a …

Proteogenomic characterization of skull-base chordoma

Q Zhang, Z Xu, R Han, Y Wang, Z Ye, J Zhu… - Nature …, 2024 - nature.com
Skull-base chordoma is a rare, aggressive bone cancer with a high recurrence rate. Despite
advances in genomic studies, its molecular characteristics and effective therapies remain …

[HTML][HTML] Comprehensive chromosome end remodeling during programmed DNA elimination

J Wang, GMB Veronezi, Y Kang, M Zagoskin… - Current Biology, 2020 - cell.com
Germline and somatic genomes are in general the same in a multicellular organism.
However, programmed DNA elimination leads to a reduced somatic genome compared to …

Asymmetric inheritance: the diversity and evolution of non-Mendelian reproductive strategies

L Ross, AJ Mongue, CN Hodson… - Annual Review of …, 2022 - annualreviews.org
The ability to reproduce is the key trait that distinguishes living organisms from inorganic
matter, and the strategies used to achieve successful reproduction are almost as diverse as …

Gradual chromosomal lagging drive programmed genome elimination in hemiclonal fishes from the genus Hypseleotris

D Dedukh, Z Majtánová, P Ráb, T Ezaz, PJ Unmack - Scientific Reports, 2024 - nature.com
Most eukaryotes maintain the stability of their cellular genome sizes to ensure genome
transmission to offspring through sexual reproduction. However, some alter their genome …

Understanding the birth of rupture-prone and irreparable micronuclei

X Guo, X Dai, X Wu, T Zhou, J Ni, J Xue, X Wang - Chromosoma, 2020 - Springer
Micronuclei are extra-nuclear bodies mainly derived from ana-telophase lagging
chromosomes/chromatins (LCs) that are not incorporated into primary nuclei at mitotic exit …

Genome elimination from the germline cells in diploid and triploid male water frogs Pelophylax esculentus

M Chmielewska, M Kaźmierczak… - Frontiers in Cell and …, 2022 - frontiersin.org
Hybridogenesis is a hemiclonal reproductive strategy in diploid and triploid hybrids. Our
study model is a frog P. esculentus (diploid RL and triploids RLL and RRL), a natural hybrid …

Variation in hybridogenetic hybrid emergence between populations of water frogs from the Pelophylax esculentus complex

D Dedukh, J Litvinchuk, A Svinin, S Litvinchuk… - PLoS …, 2019 - journals.plos.org
Many closely related species are capable of mating to produce hybrid offspring, which are
usually sterile. Nevertheless, altering the gametogenesis of hybrid offspring can rescue …