Broad-spectrum pan-genus and pan-family virus vaccines
Although the development and clinical application of SARS-CoV-2 vaccines during the
COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it …
COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it …
Nipah and Hendra viruses: deadly zoonotic paramyxoviruses with the potential to cause the next pandemic
S Gazal, N Sharma, S Gazal, M Tikoo, D Shikha… - Pathogens, 2022 - mdpi.com
Nipah and Hendra viruses are deadly zoonotic paramyxoviruses with a case fatality rate of
upto 75%. The viruses belong to the genus henipavirus in the family Paramyxoviridae, a …
upto 75%. The viruses belong to the genus henipavirus in the family Paramyxoviridae, a …
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion.
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections
and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike …
and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike …
[HTML][HTML] Learning from prepandemic data to forecast viral escape
Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
Structural basis for broad coronavirus neutralization
Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier
in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the …
in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To evaluate the …
Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination
SR Welch, JR Spengler, SC Genzer… - Science …, 2023 - science.org
Nipah virus (NiV) causes a highly lethal disease in humans who present with acute
respiratory or neurological signs. No vaccines against NiV have been approved to date …
respiratory or neurological signs. No vaccines against NiV have been approved to date …
Architecture and antigenicity of the Nipah virus attachment glycoprotein
Z Wang - Biophysical Journal, 2022 - cell.com
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic henipaviruses
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …
Vaccines to emerging viruses: Nipah and Hendra
Hendra virus (HeV) and Nipah virus (NiV) are bat-borne zoonotic para-myxoviruses
identified in the mid-to late 1990s in outbreaks of severe disease in livestock and people in …
identified in the mid-to late 1990s in outbreaks of severe disease in livestock and people in …
Principles and practical applications of structure-based vaccine design
PO Byrne, JS McLellan - Current opinion in immunology, 2022 - Elsevier
Highlights•Summary of the basic principles of structure-based vaccine design.•Review of
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …