Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …

The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Tolerance to self-antigens prevents the elimination of cancer by the immune system,. We
used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and …

Physiologic aging leads to attrition of telomeres and replicative senescence. An acceleration
of this process has been hypothesized in the progression of chronic liver disease. We …

INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …

Background Adult mesenchymal stem cells (MSCs) hold great promise for regenerative
medicine because of their self-renewal, multipotency, and trophic and immunosuppressive …

Purpose. Leukocyte telomere length (LTL) is an important biomarker of aging. The oxidative
balance score (OBS) is used to assess the oxidative stress‐related exposures of diet and …

INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant
accident exposed millions of individuals in the surrounding region to radioactive …

The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …