The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

PURPOSE: Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …

Creatine (Cr) is an important organic compound acting as intracellular high-energy
phosphate shuttle and in energy storage. While located in most cells where it plays its main …

After years of lethargy, studies on two non-conventional microstructures in time and space of
the beams used in radiation therapy are enjoying a huge revival. The first effect called …

Spatially fractionated radiation therapy (SFRT) challenges some of the classical dogmas in
conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have …

Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …

The major limitation to reaching a curative radiation dose in radioresistant tumors such as
malignant gliomas is the high sensitivity to radiation and subsequent damage of the …

To analyze the effects of the microbeam width (25, 50 and 75 µm) on the survival of 9L
gliosarcoma tumor-bearing rats and on toxicity in normal tissues in normal rats after …

The application of a microchannel proton irradiation was compared to homogeneous
irradiation in a three-dimensional human skin model. The goal is to minimize the risk of …