Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Epigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the
mechanism of how their interaction regulates aging, particularly in mammals, remains …

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
elderly population with unclear pathogenic mechanism. Herein, we detect downregulated …

Over the past decade, epigenetic clocks have emerged as powerful machine learning tools,
not only to estimate chronological and biological age but also to assess the efficacy of anti …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …