Abstract Neurofibromatosis 1 (NF1), also known as von Recklinghausen disease, is an
autosomal dominant condition caused by mutations of the NF1 gene, which is located at …

Abstract Neurofibromatosis type 1 (NF1) is a relatively common tumour predisposition
syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene …

Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties
of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients …

Abstract Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant
disorders and is caused by mutations in the NF1 gene. Mutation detection is complex due to …

Abstract Neurofibromatosis type 1 (NF1) is one of the most common inherited disorders in
humans and is caused by mutations in the NF1 gene. To date, the majority of the reported …

Leukemia results from the accumulation of multiple genetic alterations that disrupt the
control mechanisms of normal growth and differentiation. The use of inbred mouse strains …

More than 500 unrelated patients with neurofibromatosis type 1 (NF1) were screened for
mutations in the NF1 gene. For each patient, the whole coding sequence and all splice sites …

Neurofibromas are one of the most characteristic features of neurofibromatosis type 1 (NF1),
an inherited autosomal-dominant neurogenetic disorder affecting 1 in 3500 individuals …

Segmental neurofibromatosis (NF) is generally thought to result from a postzygotic NF1
(neurofibromatosis type 1) gene mutation. However, this has not yet been demonstrated at …

Neurofibroma is a benign tumor that arises from small or large nerves. This neoplastic lesion
is a common feature of neurofibromatosis type 1 (NF1), one of the most common autosomal …