Crosstalk between the nervous system and tumor microenvironment: functional aspects and potential therapeutic strategies

L Wang, J Ge, H Han, Y Jia, Y Qin - Cancer Letters, 2024 - Elsevier
Recent advancements in understanding the tumor microenvironment (TME) have
highlighted the critical role of the nervous system in cancer progression. This review …

Nerve input to tumours: Pathophysiological consequences of a dynamic relationship

C Hutchings, JA Phillips, MBA Djamgoz - Biochimica et Biophysica Acta …, 2020 - Elsevier
It is well known that tumours arising in different organs are innervated and that 'perineural
invasion'(cancer cells escaping from the tumour by following the nerve trunk) is a negative …

Repurposing of chronically used drugs in cancer therapy: a chance to grasp

MA Hijazi, A Gessner, N El-Najjar - Cancers, 2023 - mdpi.com
Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

[HTML][HTML] The sympathetic nervous system shapes the tumor microenvironment to impair chemotherapy response

AV Manoleras, EK Sloan, A Chang - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
The tumor microenvironment influences cancer progression and response to treatments,
which ultimately impacts the survival of patients with cancer. The sympathetic nervous …

Role of α-and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease

M Archer, N Dogra, Z Dovey, T Ganta, HS Jang… - Cell Communication and …, 2021 - Springer
The urinary tract is highly innervated by autonomic nerves which are essential in urinary
tract development, the production of growth factors, and the control of homeostasis. These …

Autonomic nervous system control of multiple myeloma

Y Cheng, F Sun, A D'Souza, B Dhakal, M Pisano… - Blood reviews, 2021 - Elsevier
The autonomic nervous system (ANS), which consists of antagonistic sympathetic
(adrenergic) and parasympathetic (cholinergic) arms, has emerged as an important …

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

PGS Braga, JS Vieira, ARB Gurgel… - Frontiers in …, 2024 - frontiersin.org
Despite advances in cancer treatment, current cancer incidence and prevalence still
demand multimodal treatments to enhance survival and clinical outcomes. Drugs used in …

Increased sympathetic nervous system impairs prognosis in lung cancer patients: a scoping review of clinical studies

FT Garramona, TF Cunha, JS Vieira… - Lung cancer …, 2023 - Taylor & Francis
Aim: To summarize current knowledge, gaps, quality of the evidence and show main results
related to the role of the autonomic nervous system in lung cancer. Methods: Studies were …

Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation

H Xia, TJ Jerde, JC Fehrenbacher - Frontiers in Molecular …, 2024 - frontiersin.org
Introduction The prostate is densely innervated like many visceral organs and glands.
However, studies to date have focused on sympathetic and parasympathetic nerves and …

Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers

RK Tiwari, SG Rawat, S Rai, A Kumar - Endocrine, 2025 - Springer
The word “cancer” evokes myriad emotions, ranging from fear and despair to hope and
determination. Cancer is aptly defined as a complex and multifaceted group of diseases that …