Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

Vascular tissue engineering has made prodigious progress in recent years by converging
multidisciplinary approaches. Latest technological advancements foster the development of …

We developed a tissue-engineered vascular graft (TEVG) for use in children and present
results of a US Food and Drug Administration (FDA)–approved clinical trial evaluating this …

The past two decades reveal a growing role of continuum biomechanics in understanding
homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly …

Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

Background Tissue-engineered vascular grafts (TEVGs) have the potential to advance the
surgical management of infants and children requiring congenital heart surgery by creating …

Vascular tissue engineering is a rapidly growing field of regenerative medicine, which
strives to find innovative solutions for vascular reconstruction. Considering the limited …

Arterial growth and remodeling at the tissue level is driven by mechanobiological processes
at cellular and sub-cellular levels. Although it is widely accepted that cells seek to promote …

Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty
of scaling production of these cell-or biologic-based products has hindered …

Mismatch of mechanical properties between highly deformable biomedical materials and
adjacent native tissue might lead to short and long term health impairment. The capability of …