Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Drug resistance developed towards conventional therapy is one of the important reasons for
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …

DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage
exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes …

Genomic and mitochondrial DNA molecules are exposed continuously for a damaging
activity of chemical, physical, and internal genotoxicants. When DNA repair machinery is not …

Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate
and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which …