The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

As a widely recognized standard regimen, R-CHOP (rituximab plus cyclophosphamide,
doxorubicin, vincristine, and prednisone) is able to cure two-thirds patients with diffuse large …

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the
exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic …

CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα,
which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat …

Immunogenic cell death (ICD) is a special pattern of tumor cell death, enabling to elicit tumor‐
specific immune response via the release of damage‐associated molecular patterns and …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

Background Immunotherapy has emerged as a novel strategy for cancer treatment following
surgery, radiotherapy, and chemotherapy. Immune checkpoint blockade and Chimeric …

The oncogene MYC is dysregulated in a host of human cancers, and as an important point
of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in …